Metabolism

Cantor Lab

The Cantor Lab studies human cell physiology and how it is influenced by environmental factors with relevance to cancer and immunology

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The Cantor lab is jointly affiliated with the Morgridge Institute for Research and the Department of Biochemistry at the University of Wisconsin-Madison. 

Our guiding hypothesis is that conventional models and methods have together masked key insights into understanding human cell physiology and drug efficacy. We test this through a variety of approaches at the interface of biology and engineering – integrating tools in biochemistry, molecular biology, metabolomics, functional genomics, and chemical genetics. We also have a strong interest in building and using tools that more faithfully model environmental contributions to human cell biology. Our overall goal is to advance the current understanding of how human cells facilitate their growth and how environmental factors influence this process – with a particular focus on blood cancers and normal immune cells. Ultimately, we hope to transition these insights into new strategies for (blood) cancer therapy that have a greater likelihood of successful translation.

We are actively recruiting team members. Learn more >

Principal Investigator Jason Cantor

Jason earned his B.S. in Chemical Engineering (2004) magna cum laude from Cornell University, and then completed his Ph.D. in Chemical Engineering (2010) from the University of Texas at Austin. Under the guidance of George Georgiou, Jason’s doctoral research focused on the development of new strategies to engineer therapeutic enzymes with reduced immunogenicity for cancer therapy, and was supported, in part, through a graduate fellowship awarded by the U.S. Department of Homeland Security. Jason then carried out his postdoctoral research in the laboratory of David M. Sabatini at the Whitehead Institute for Biomedical Research (MIT). There, he focused on designing new tools to better understand how environmental factors influence the metabolic regulation of cancer cells. His postdoctoral research was funded, in part, through fellowships awarded by both the American Cancer Society and the Koch Institute for Integrative Cancer Research at MIT, and was also later recognized with a Margaret and Herman Sokol Postdoctoral Award from the Whitehead Institute. In August 2018, Jason became a Metabolism Investigator at the Morgridge Institute for Research and an Assistant Professor in the Departments of Biochemistry and Biomedical Engineering at the University of Wisconsin-Madison.

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